Targeted antigen delivery system
靶向抗原遞送系統
Targeted antigen delivery system
靶向抗原遞送系統
Targeted indication
Vaccine or cancer immunotherapy
Status
Preclinical study
Key features
- • High safety profile
- • Highly immunogenic protein
- • The platform technology could be applied to different vaccines products
Market
The fusion protein made using this technology can be used alone as vaccine candidates or formulated with adjuvant. In vaccination, subunit vaccines are likely the new generation vaccines because of their safety and efficiency. This technology has been applied in survivin subunit vaccine for cancer immunotherapy and Zika subunit vaccines. We expect this technology to be used in the development of new and better vaccines, especially for the unment medical need disease areas.
MODE OF ACTION
Dendritic cells express various Fcγ receptors (FcγRs), which mediate internalization of antigen-antibody complexes and regulate immune responses. Targeting of antigen to dendritic cells via FcγRs potentially constitutes an effective strategy for modulation of antigen-specific immune responses. Formyl peptide receptor-like inhibitory protein (FLIPr), secreted by Staphylococcus aureus, can bind to various Fcγ receptors. Therefore, antigen-FLIPr fusion proteins can guide antigens to FcγR and induce potent immune responses.
EXPERIMENTAL RESULTS
INTELLECTUAL PROPERTY
SELECTED PUBLICATIONS
Manuscript in preparation
BUSINESS OPPORTUNITY
License and/or Collaboration and Sponsored Research
CONTACT
service@biip-dcc.org